Author information Article notes Copyright and License information Disclaimer. We were unable to select any cells transduced with both vectors, indicating that simultaneous depletion of both Topo II isoforms is lethal to this cell line. GF-7 reactivity with cells in different phases of mitosis was verified by immunoperoxidase staining Fig. The frequent restitution events indicate that the increase in the fraction of cells with G 2 DNA content upon Topo II depletion is due, at least in part, to the failure of mitosis and accumulation of polyploid cells. TOP73 appears to represent such a variant.
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See the Ordway Research Institute. View Gary Lyman's profile on LinkedIn, the world's largest professional community. a postdoctoral fellowship with Professor Marvin Zelen at the Harvard School of Public Thomas Ordway Professor of Medicine and Cancer Center Director.
validation; Paulo Mendonc ̧a for valuable technical discussions; and Gary Schools from the Ordway Research Institute for assisting with the result validation .
Only BrdU-positive cells are shown.
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A Mitotic spread images of different types of chromosomal morphology. Support Center Support Center.
Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains. As a result of impaired mitosis, Topo II depletion leads to a failure of cell division, with the ensuing cell death mitotic catastrophe or restitution. Much of our knowledge on the biological functions of Topo II comes from the studies utilizing small-molecule Topo II inhibitors, several of which have been developed as anticancer drugs.
o@ 23 shared research output Southwestern Medical School; University of Texas Health Science Center; University of Texas Southwestern Medical Center; Harry S. Moss Heart OrdwayG.
The 2nd World Conference of ImmunoOncology (WCIO)
A. Univ. Valeria Ossovskaya, Chang-Uk Lim, Gary Schools, Swathi Kalurupalle, Igor B. of iniparib in combination with these DNA-damaging agents in clinical studies.
Congratulations to Jinjin Zhu for successfully defending her graduate PhD thesis! SMC complexes and topoisomerase II work together so that sister chromatids can work apart.
Gary H. Lyman, MD, MPH « Summit on National and Global Cancer Health Disparities
Luke, Jinjin, Sneha, and Ali presented posters at the meeting and Bonnie gave a talk in the Pattern Formation session. TOP73 appears to represent such a variant. He is also active in the American Association for Cancer Research and the Institute of Medicine as well as the American Society of Hematology where he serves on the Quality and Guideline Oversight Committees and Chairs the forthcoming guideline on cancer and thrombosis.
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